Anti-Human ITSN1 Polyclonal Antibody
- Cat. No.：RB9THD585014
- Price：Negotiable
- Clicks：146
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Rat, Human, Mouse |
| Target | ITSN, ITSN1, Intersectin-1, SH3 domain-containing protein 1A, SH3D1A, SH3P17 |
| Immunogen | E. coli - derived recombinant Human ITSN1 (Asp1216-Leu1445). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q15811 |
| Background | Intersectin-1 (ITSN1) is a ~195 kDa protein. Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles. Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors. 1. Hussain, NK. et al. (2001) Nature cell biology 3, 927-32. PMID: 11584276 2. Almeida-Souza, L. et al. (2018) Cell 174, 325-337.e14. PMID: 29887380 3. Teckchandani, A. et al. (2012) Molecular biology of the cell 23, 2905-16. PMID: 22648170 4. Jenna, S. et al. (2002) The Journal of biological chemistry 277, 6366-73. PMID: 11744688 |
| Note | For research use only |
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