Anti-Human HTRA3 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Mouse, Human, Rat
Target	EC:3.4.21.-, HTRA3, High-temperature requirement factor A3, PRSP, Pregnancy-related serine protease, Serine protease HTRA3
Immunogen	E. coli - derived recombinant Human HTRA3 (Asn141-Pro333).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	P83110
Background	Serine protease HTRA3 is a ~48 kDa protein. Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. 1. Singh, H. et al. (2011) Human reproduction (Oxford, England) 26, 748-57. PMID: 21321049 2. Singh, H. et al. (2012) BioTechniques 52, 23-8. PMID: 22229724
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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