Anti-Human HTRA3 Polyclonal Antibody
- Cat. No.：RB9THX117014
- Price：Negotiable
- Clicks：166
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Mouse, Human, Rat |
| Target | EC:3.4.21.-, HTRA3, High-temperature requirement factor A3, PRSP, Pregnancy-related serine protease, Serine protease HTRA3 |
| Immunogen | E. coli - derived recombinant Human HTRA3 (Asn141-Pro333). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | P83110 |
| Background | Serine protease HTRA3 is a ~48 kDa protein. Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. 1. Singh, H. et al. (2011) Human reproduction (Oxford, England) 26, 748-57. PMID: 21321049 2. Singh, H. et al. (2012) BioTechniques 52, 23-8. PMID: 22229724 |
| Note | For research use only |
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