Anti-Human LACTB Polyclonal Antibody
- Cat. No.：RB9THD571014
- Price：Negotiable
- Clicks：386
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human, Mouse |
| Target | EC:3.4.-.-, LACTB, MRPL56, Serine beta-lactamase-like protein LACTB, mitochondrial |
| Immunogen | E. coli - derived recombinant Human LACTB (Cys100-Ser256). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | P83111 |
| Background | Serine beta-lactamase-like protein LACTB, mitochondrial is a ~60 kDa protein. Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism. 1. Keckesova, Z. et al. (2017) Nature 543, 681-686. PMID: 28329758 |
| Note | For research use only |
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