Anti-Human RPE65 Polyclonal Antibody
- Cat. No.：RB9THD563014
- Price：Negotiable
- Clicks：524
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Mouse, Human, Rat |
| Target | All-trans-retinyl-palmitate hydrolase, EC:3.1.1.64, EC:5.3.3.22, Lutein isomerase, Meso-zeaxanthin isomerase, RPE65, Retinal pigment epithelium-specific 65 kDa protein, Retinoid isomerohydrolase, Reti |
| Immunogen | E. coli - derived recombinant Human RPE65 (Met1-Ser533). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q16518 |
| Background | Retinoid isomerohydrolase (RPE65) is a ~60 kDa protein. Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. 1. Moiseyev, G. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 12413-8. PMID: 16116091 2. Jacobson, SG. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 15123-8. PMID: 17848510 3. Shyam, R. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 10882-10887. PMID: 28874556 |
| Note | For research use only |
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