| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human |
| Target | ARHGEF36, DNMBP, Dynamin-binding protein, KIAA1010, Scaffold protein Tuba, TUBA |
| Immunogen | E. coli - derived recombinant Human DNMBP (Met1-Leu202). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q6XZF7 |
| Background | Dynamin-binding protein (DNMBP) is a ~177 kDa protein. Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells. Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation. Plays a role in ciliogenesis. May play a role in membrane trafficking between the cell surface and the Golgi. 1. Otani, T. et al. (2006) The Journal of cell biology 175, 135-46. PMID: 17015620 2. Rajabian, T. et al. (2009) Nature cell biology 11, 1212-8. PMID: 19767742 3. Qin, Y. et al. (2010) The Journal of cell biology 189, 661-9. PMID: 20479467 |
| Note | For research use only |