| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Rat, Mouse, Human |
| Target | KH domain-containing, RNA-binding, signal transduction-associated protein 3, KHDRBS3, RNA-binding protein T-Star, SALP, SLM-2, SLM2, Sam68-like mammalian protein 2, Sam68-like phosphotyrosine protein |
| Immunogen | E. coli - derived recombinant Human KHDRBS3 (Asn51-Gly176). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | O75525 |
| Background | KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) is a ~38 kDa protein. RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6. 1. Lee, J. et al. (1999) Gene 240, 133-47. PMID: 10564820 2. Ray, D. et al. (2009) Nature biotechnology 27, 667-70. PMID: 19561594 3. Feracci, M. et al. (2016) Nature communications 7, 10355. PMID: 26758068 4. Cohen, CD. et al. (2005) Journal of the American Society of Nephrology : JASN 16, 1958-65. PMID: 15901763 |
| Note | For research use only |