Anti-Human YJEFN3 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Human
Target	AIBP2, ApoA-I-binding protein 2, YJEFN3, YjeF N-terminal domain-containing protein 3, YjeF_N3, hYjeF_N3
Immunogen	E. coli - derived recombinant Human YJEFN3 (Met1-Leu299).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	A6XGL0
Background	YjeF N-terminal domain-containing protein 3 (YJEFN3) is a ~32 kDa protein. May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence. May play a role in spermiogenesis and oogenesis. 1. Rudolph, C. et al. (2007) Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 39, 322-35. PMID: 17533573
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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