Anti-Human DDX46 Polyclonal Antibody
- Cat. No.：RB9THD537014
- Price：Negotiable
- Clicks：241
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Rat, Human, Mouse |
| Target | DDX46, DEAD box protein 46, EC:3.6.4.13, KIAA0801, PRP5 homolog, Probable ATP-dependent RNA helicase DDX46 |
| Immunogen | E. coli - derived recombinant Human DDX46 (Asp322-Lys765). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q7L014 |
| Background | Probable ATP-dependent RNA helicase DDX46 is a ~117 kDa protein. Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site. 1. Will, CL. et al. (2002) The EMBO journal 21, 4978-88. PMID: 12234937 2. Zhang, Z. et al. (2020) Nature 583, 310-313. PMID: 32494006 3. Tholen, J. et al. (2022) Science (New York, N.Y.) 375, 50-57. PMID: 34822310 4. Yang, F. et al. (2023) Nature communications 14, 897. PMID: 36797247 |
| Note | For research use only |
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