Anti-Human PDE12 Polyclonal Antibody
- Cat. No.：RB9THD532014
- Price：Negotiable
- Clicks：356
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Mouse, Human, Rat |
| Target | 2',5'-phosphodiesterase 12, 2'-PDE, 2-PDE, EC:3.1.13.4, EC:3.1.4.-, Mitochondrial deadenylase, PDE12 |
| Immunogen | E. coli - derived recombinant Human PDE12 (Thr276-Lys609). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q6L8Q7 |
| Background | 2',5'-phosphodiesterase 12 (PDE12) is a ~67 kDa protein. Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells. 1. Wood, ER. et al. (2015) The Journal of biological chemistry 290, 19681-96. PMID: 26055709 2. Rorbach, J. et al. (2011) Nucleic acids research 39, 7750-63. PMID: 21666256 3. Estrella, MA. et al. (2018) Scientific reports 8, 16294. PMID: 30389976 |
| Note | For research use only |
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