Anti-Human EXTL3 Polyclonal Antibody
- Cat. No.：RB9THD524014
- Price：Negotiable
- Clicks：284
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human, Mouse |
| Target | EC:2.4.1.223, EXT-related protein 1, EXTL1L, EXTL3, EXTR1, Exostosin-like 3, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Hereditary multiple exostoses gene isolog, KIAA |
| Immunogen | E. coli - derived recombinant Human EXTL3 (Tyr341-Ile540). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | O43909 |
| Background | Exostosin-like 3 (EXTL3) is a ~104 kDa protein. Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker. May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity). Lacks glucuronyl transferase II (GlcAT-II) activity. Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). 1. Oud, MM. et al. (2017) American journal of human genetics 100, 281-296. PMID: 28132690 2. Volpi, S. et al. (2017) The Journal of experimental medicine 214, 623-637. PMID: 28148688 3. Kim, BT. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 7176-81. PMID: 11390981 4. Wilson, LFL. et al. (2022) Nature communications 13, 3314. PMID: 35676258 5. Lai, Y. et al. (2012) Immunity 37, 74-84. PMID: 22727489 |
| Note | For research use only |
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