Anti-Human KIDINS220 Polyclonal Antibody
- Cat. No.：RB9THD508014
- Price：Negotiable
- Clicks：351
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Rat, Human |
| Target | ARMS, Ankyrin repeat-rich membrane-spanning protein, KIAA1250, KIDINS220, Kinase D-interacting substrate of 220 kDa |
| Immunogen | E. coli - derived recombinant Human KIDINS220 (Met1-Lys168). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q9ULH0 |
| Background | Kinase D-interacting substrate of 220 kDa (KIDINS220) is a ~196 kDa protein. Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. |
| Note | For research use only |
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