Anti-Human SMPDL3B Polyclonal Antibody
- Cat. No.：RB9THD667014
- Price：Negotiable
- Clicks：184
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human |
| Target | ASM-like phosphodiesterase 3b, ASML3B, ASMLPD, Acid sphingomyelinase-like phosphodiesterase 3b, EC:3.1.4.-, SMPDL3B |
| Immunogen | E. coli - derived recombinant Human SMPDL3B (Gly21-Gly433). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q92485 |
| Background | Acid sphingomyelinase-like phosphodiesterase 3b (SMPDL3B) is a ~50 kDa protein. Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling. Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro). 1. Heinz, LX. et al. (2015) Cell reports 11, 1919-28. PMID: 26095358 |
| Note | For research use only |
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