| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human |
| Target | 250 kDa centrosomal protein, C-Nap1, CEP2, CEP250, CNAP1, Centrosomal Nek2-associated protein 1, Centrosomal protein 2, Centrosome-associated protein CEP250, Cep250 |
| Immunogen | E. coli - derived recombinant Human CEP250 (Arg40-Thr293). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q9BV73 |
| Background | Centrosome-associated protein CEP250 is a ~281 kDa protein. Plays an important role in centrosome cohesion during interphase. Recruits CCDC102B to the proximal ends of centrioles. Maintains centrosome cohesion by forming intercentriolar linkages. Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion. May be involved in ciliogenesis. 1. Xia, Y. et al. (2018) Journal of cell science 131. PMID: 30404835 2. Mahen, R. (2022) PLoS biology 20, e3001854. PMID: 36282799 3. de Castro-Miró, M. et al. (2016) PloS one 11, e0168966. PMID: 28005958 |
| Note | For research use only |