Anti-Human CRAT Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Human, Rat, Mouse
Target	CAT, CAT1, CRAT, Carnitine O-acetyltransferase, Carnitine acetylase, Carnitine acetyltransferase, CrAT, EC:2.3.1.137, EC:2.3.1.7
Immunogen	E. coli - derived recombinant Human CRAT (His31-Glu297).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	P43155
Background	Carnitine O-acetyltransferase (CRAT) is a ~70 kDa protein. Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates. 1. Govindasamy, L. et al. (2004) Journal of structural biology 146, 416-24. PMID: 15099582 2. Drecourt, A. et al. (2018) American journal of human genetics 102, 266-277. PMID: 29395073 3. Violante, S. et al. (2013) Biochimica et biophysica acta 1832, 773-9. PMID: 23485643
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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