Anti-Human PDE8A Polyclonal Antibody
- Cat. No.：RB9THD652014
- Price：Negotiable
- Clicks：281
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human |
| Target | EC:3.1.4.53, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, PDE8A |
| Immunogen | E. coli - derived recombinant Human PDE8A (Ser480-Glu829). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | O60658 |
| Background | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A) is a ~93 kDa protein. Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine. 1. Wang, H. et al. (2008) Biochemistry 47, 12760-8. PMID: 18983167 2. Brown, KM. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, E1533-42. PMID: 23509299 |
| Note | For research use only |
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