Anti-CCHFV GP38 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Crimean-Congo hemorrhagic fever virus
Target	15 kDa protein, 37 kDa protein, 75 kDa protein, Envelopment polyprotein, GP, GP38, Gc, Glycoprotein C, Glycoprotein G1, Glycoprotein G2, Glycoprotein N, Gn, M polyprotein, Mucin-like variable region,
Immunogen	E. coli - derived recombinant CCHFV GP38 (Asn248-Ser515).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	Q8JSZ3
Background	Envelopment polyprotein (GP38) is a ~186 kDa protein. Plays a role in virion attachment to host receptor. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis Glycoprotein N probably locks the Gn-Gc complex in a prefusion state. 1. Xu, ZS. et al. (2024) Cell research 34, 140-150. PMID: 38182887 2. Simon, M. et al. (2009) The Journal of general virology 90, 210-5. PMID: 19088291 3. Mishra, AK. et al. (2022) Science (New York, N.Y.) 375, 104-109. PMID: 34793197
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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