Anti-FBXW7 Polyclonal Antibody
- Cat. No.：RB9THP138014
- Price：Negotiable
- Clicks：404
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human, Mouse, Rat, Bovine |
| Target | Archipelago homolog, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, F-box/WD repeat-containing protein 7, FBW7, FBX30, FBXW7, SEL-10, SEL10, hAgo, hCdc4 |
| Immunogen | E. coli - derived recombinant human FBXW7 (Asp279-Val515). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Shipping Condition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q969H0 |
| Observed Molecular Weight | 100 kDa |
| Background | F-box/WD repeat-containing protein 7 (FBXW7) is a ~79 kDa protein. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1, MLST8, RICTOR, and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation. Involved in bone homeostasis and negative regulation of osteoclast differentiation. 1. Hao, B. et al. (2007) Molecular cell 26, 131-43. PMID: 17434132 2. Duda, DM. et al. (2012) Molecular cell 47, 371-82. PMID: 22748924 3. Gorelik, M. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, 3527-32. PMID: 26976582 4. Yalla, K. et al. (2018) Molecular psychiatry 23, 1278-1286. PMID: 28727686 5. Zhang, E. et al. (2022) Cancer science 113, 91-108. PMID: 34741373 6. Stephenson, SEM. et al. (2022) American journal of human genetics 109, 601-617. PMID: 35395208 7. Zhang, Q. et al. (2016) Molecular cell 61, 419-433. PMID: 26774286 |
| Note | For research use only |
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