Anti-Human IL2 Recombinant Antibody
- Cat. No.：RB9THX061013
- Price：Negotiable
- Clicks：261
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Human |
| Clonality | Monoclonal |
| Isotype | scFv-hFc |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, in vivo and in vitro study |
| Species Reactivity | Homo sapiens (Human) |
| Target | Aldesleukin, IL-2, IL2, Interleukin-2, T-cell growth factor, TCGF |
| Storage Buffer | 0.01M PBS pH 7.4 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Shipping Condition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Accession Number | P60568 |
| Background | Interleukin-2 (IL2) is a ~17 kDa protein. Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. 1. Mingari, MC. et al. (1984) Nature 312, 641-3. PMID: 6438535 2. Wang, X. et al. (2005) Science (New York, N.Y.) 310, 1159-63. PMID: 16293754 3. Stauber, DJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 2788-93. PMID: 16477002 4. Miyazaki, T. et al. (1994) Science (New York, N.Y.) 266, 1045-7. PMID: 7973659 5. Kirken, RA. et al. (1995) Cytokine 7, 689-700. PMID: 8580378 6. Osinalde, N. et al. (2015) Proteomics 15, 520-31. PMID: 25142963 7. Holbrook, NJ. et al. (1984) Proceedings of the National Academy of Sciences of the United States of America 81, 1634-8. PMID: 6608729 |
| Note | For research use only |
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