Anti-Human ErbB3/Her3 Reference Antibody

Form	Liquid
Host Species	Human
Clonality	Monoclonal
Isotype	IgG1, kappa
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Endotoxin Level	< 10 EU/mg
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Species Reactivity	Human
Storage Buffer	0.01 M PBS pH 7.4
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -102°C long term.
Product Usage Information	ELISA: 1:2000-1:20000
Accession Number	P21860
Background	Receptor tyrosine-protein kinase erbB-3 (ERBB3/HER3) is a ~148 kDa protein. Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. 1. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778 2. Kinugasa, Y. et al. (2004) Biochemical and biophysical research communications 321, 1045-9. PMID: 15358134 3. Braunstein, EM. et al. (2016) Leukemia 30, 2242-2245. PMID: 27416908
Note	For research use only.

For Research Use Only. Not for Diagnostic Procedures.

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