Anti-Human EREG/Epiregulin Reference Antibody

Form	Liquid
Host Species	Human
Clonality	Monoclonal
Isotype	IgG4, kappa
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Endotoxin Level	< 10 EU/mg
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Species Reactivity	Human
Storage Buffer	0.01 M PBS pH 7.4
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Product Usage Information	ELISA: 1:2000-1:20000
Accession Number	O14944
Background	Proepiregulin (EREG) is a ~19 kDa protein. Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation. 1. Komurasaki, T. et al. (1997) Oncogene 15, 2841-8. PMID: 9419975 2. Riese, DJ. et al. (2014) Seminars in cell & developmental biology 28, 49-56. PMID: 24631357
Note	For research use only.

For Research Use Only. Not for Diagnostic Procedures.

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