Anti-TIMM23 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Human, Rat, Mouse
Target	Mitochondrial import inner membrane translocase subunit Tim23, TIM23, TIMM23
Immunogen	E. coli - derived recombinant TIMM23 (Glu2-Arg72).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	O14925, O35093, Q9WTQ8, Q5SRD1
Background	Mitochondrial import inner membrane translocase subunit Tim23 is a ~21 kDa protein. Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has a role in the activation of stress-induced mitophagy by protecting PINK1 from OMA1-mediated degradation and facilitating its accumulation at the outer mitochondrial membrane in response to depolarization. 1. Bauer, MF. et al. (1999) Journal of molecular biology 289, 69-82. PMID: 10339406 2. Akabane, S. et al. (2023) Cell reports 42, 112454. PMID: 37160114
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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