Research Grade Lerodalcibep
- Cat. No.：RB9THD700026
- Price：Negotiable
- Clicks：433
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Clonality | Monoclonal |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin Level | < 10 EU/mg |
| Applications | Functional assay |
| Species Reactivity | Human |
| Target | EC:3.4.21.-, NARC-1, NARC1, Neural apoptosis-regulated convertase 1, PC9, PCSK9, Proprotein convertase 9, Proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9 |
| Storage Buffer | 0.01M PBS pH 7.4 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Accession Number | Q8NBP7 |
| Background | Proprotein convertase subtilisin/kexin type 9 is a ~74 kDa protein. Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. 1. Poirier, S. et al. (2008) The Journal of biological chemistry 283, 2363-72. PMID: 18039658 2. Nassoury, N. et al. (2007) Traffic (Copenhagen, Denmark) 8, 718-32. PMID: 17461796 3. Fan, D. et al. (2008) Biochemistry 47, 1631-9. PMID: 18197702 4. Mayer, G. et al. (2008) The Journal of biological chemistry 283, 31791-801. PMID: 18799458 5. Chen, Y. et al. (2011) Biochemical and biophysical research communications 415, 515-8. PMID: 22074827 6. Jonas, MC. et al. (2008) EMBO reports 9, 916-22. PMID: 18660751 |
| Note | For research use only. |
Related Products:
| Product Name | Clicks |
|---|---|
| 抗口蹄疫病毒非结构蛋白单克隆抗体 | 4870 |
| 抗猪弓形虫单克隆抗体 | 5142 |
| 抗猪肺炎支原体单克隆抗体 | 4590 |
| 抗星状病毒单克隆抗体h | 4912 |
| 抗猪传染性胃肠炎病毒单克隆抗体 | 4872 |
| 抗猪轮状病毒单克隆抗体H | 5079 |
| 抗猪伪狂犬病毒单克隆抗体 | 5235 |
| 抗猪伪狂犬病毒单克隆抗体 | 4858 |
| 抗猪塞内加谷病毒单克隆抗体 | 4885 |
| 抗猪A型流感病毒单克隆抗体 | 4951 |
| 抗猪A型轮状病毒单克隆抗体 | 5377 |
| 抗猪繁殖与呼吸障碍综合征病毒单克隆抗体 | 5409 |
| 抗猪链球菌35个型病毒单克隆抗体 | 5423 |
| 抗非洲猪瘟病毒单克隆抗体 | 4842 |
| 禽支原体单克隆抗体 | 4807 |
| 抗通用型禽流感单克隆抗体 | 5515 |
| 抗新城疫单克隆抗体 | 4888 |
| 抗甲型流感 H5/H7 /H9亚型单克隆抗体H | 5014 |
| 抗传染性支气管炎病毒单克隆抗体H | 4754 |
| 抗传染性法氏囊病毒单克隆抗体H | 5710 |