Research Grade BMS-962476
- Cat. No.：RB9THD700016
- Price：Negotiable
- Clicks：228
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Clonality | Monoclonal |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin Level | < 10 EU/mg |
| Applications | Functional assay |
| Species Reactivity | Human |
| Target | EC:3.4.21.-, NARC-1, NARC1, Neural apoptosis-regulated convertase 1, PC9, PCSK9, Proprotein convertase 9, Proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9 |
| Storage Buffer | 0.01M PBS pH 7.4 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Accession Number | Q8NBP7 |
| Background | Proprotein convertase subtilisin/kexin type 9 is a ~74 kDa protein. Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. 1. Poirier, S. et al. (2008) The Journal of biological chemistry 283, 2363-72. PMID: 18039658 2. Nassoury, N. et al. (2007) Traffic (Copenhagen, Denmark) 8, 718-32. PMID: 17461796 3. Fan, D. et al. (2008) Biochemistry 47, 1631-9. PMID: 18197702 4. Mayer, G. et al. (2008) The Journal of biological chemistry 283, 31791-801. PMID: 18799458 5. Chen, Y. et al. (2011) Biochemical and biophysical research communications 415, 515-8. PMID: 22074827 6. Jonas, MC. et al. (2008) EMBO reports 9, 916-22. PMID: 18660751 |
| Note | For research use only. |
Related Products:
| Product Name | Clicks |
|---|---|
| 空肠弯曲菌单克隆抗体 | 7705 |
| 人触珠蛋白单克隆抗体 | 7796 |
| 贾第鞭毛虫单克隆抗体 | 7546 |
| 阿米巴单克隆抗体 | 7977 |
| 胃蛋白酶单克隆抗体 | 7542 |
| 胃蛋白酶原II单克隆抗体 | 7645 |
| 胃蛋白酶原I单克隆抗体 | 7484 |
| 艰难梭菌毒素A单克隆抗体 | 7554 |
| 艰难梭菌毒素B单克隆抗体 | 7957 |
| 艰难梭菌GDH单克隆抗体 | 7788 |
| 诺如病毒单克隆抗体 | 7404 |
| 伤寒沙门氏菌单克隆抗体 | 7590 |
| 鼠疫耶尔森菌F1单克隆抗体 | 6949 |
| 幽门螺杆菌单克隆抗体 | 7472 |
| 钙卫蛋白单克隆抗体 | 7319 |
| 乳铁蛋白单克隆抗体 | 7557 |
| 转铁蛋白单克隆抗体 | 7627 |
| 血红蛋白单克隆抗体 | 7383 |
| 腺病毒单克隆抗体 | 7558 |
| 轮状病毒单克隆抗体 | 7913 |