Anti-Human TRAIL R2/TNFRSF10B Reference Antibody

Form	Liquid
Host Species	Human
Clonality	Monoclonal
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Endotoxin Level	< 10 EU/mg
Applications	ELISA, FACS, Functional assay
Species Reactivity	Human
Target	CD262, DR5, Death receptor 5, KILLER, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAIL-R2, TRAILR2, TRICK2, Tumor necrosis factor receptor superfamily member 10B, Z
Storage Buffer	0.01M PBS pH 7.4
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Product Usage Information	ELISA: 1:2000-1:20000
Accession Number	O14763
Background	Tumor necrosis factor receptor superfamily member 10B (DR5) is a ~47 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. 1. Hymowitz, SG. et al. (1999) Molecular cell 4, 563-71. PMID: 10549288
Note	For research use only.

For Research Use Only. Not for Diagnostic Procedures.

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