Anti-Human CD71/TFRC Recombinant Antibody
- Cat. No.：RB9THY036033
- Price：Negotiable
- Clicks：456
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, block |
| Species Reactivity | Human |
| Target | CD71, T9, TFRC, TR, TfR, TfR1, Transferrin receptor protein 1, Transferrin receptor protein 1, serum form, Trfr, p90, sTfR |
| Storage Buffer | 0.01M PBS pH 7.4 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Product Usage Information | ELISA: 1:2000-1:20000 |
| Accession Number | P02786 |
| Background | Transferrin receptor protein 1 (CD71/TFRC) is a ~84 kDa protein. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. 1. Senyilmaz, D. et al. (2015) Nature 525, 124-8. PMID: 26214738 2. Jabara, HH. et al. (2016) Nature genetics 48, 74-8. PMID: 26642240 |
| Note | For research use only |
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