Anti-Human CD117/KIT Recombinant Antibody
- Cat. No.：RB9THY163013
- Price：Negotiable
- Clicks：186
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a, kappa |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Species Reactivity | Human |
| Target | CD117, EC:2.7.10.1, KIT, Mast/stem cell growth factor receptor Kit, PBT, Piebald trait protein, Proto-oncogene c-Kit, SCFR, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarc |
| Storage Buffer | 0.01M PBS pH 7.4 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Product Usage Information | ELISA: 1:2000-1:20000 |
| Accession Number | P10721 |
| Background | Mast/stem cell growth factor receptor Kit (CD117) is a ~109 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. |
| Note | For research use only |
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