Anti-Mouse TIGIT Recombinant Antibody
- Cat. No.：RB9TMS739023
- Price：Negotiable
- Clicks：176
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1, kappa |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Species Reactivity | Mouse |
| Target | T-cell immunoreceptor with Ig and ITIM domains, Tigit, V-set and transmembrane domain-containing protein 3, Vstm3 |
| Storage Buffer | 0.01M PBS pH 7.4 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Product Usage Information | ELISA: 1:2000-1:20000 |
| Accession Number | P86176 |
| Background | T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades. |
| Note | For research use only |
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