Anti-Mouse CD28 Recombinant Antibody
- Cat. No.：RB9TMY422023
- Price：Negotiable
- Clicks：270
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Armenian hamster |
| Clonality | Monoclonal |
| Isotype | IgG |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, FACS, Functional assay, Research in vivo, in vitro T cell stimulation/activation |
| Species Reactivity | Mouse |
| Target | CD28, Cd28, T-cell-specific surface glycoprotein CD28 |
| Storage Buffer | 0.01M PBS pH 7.4 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Product Usage Information | ELISA: 1:2000-1:20000 |
| Accession Number | P31041 |
| Background | T-cell-specific surface glycoprotein CD28 is a ~25 kDa protein. Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis. Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells. 1. Shahinian, A. et al. (1993) Science (New York, N.Y.) 261, 609-12. PMID: 7688139 |
| Note | For research use only |
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