InVivo Plus Mouse CTLA-4 Antibody(9D9)
- Cat. No.：RB9TMB651209
- Price：Negotiable
- Clicks：406
Product Detail
Product Parameters
| Product Description | The 9D9 monoclonal antibody recognizes mouse CTLA-4 (CD152), a 33-kDa CD28-family inhibitory receptor expressed on activated T and B cells. CTLA-4 binds the B7 ligands CD80 and CD86 and delivers negative regulatory signals that control T-cell activation, maintain tolerance, and support normal immune homeostasis. The essential role of CTLA-4 is highlighted by CTLA-4–deficient mice, which develop fatal lymphoproliferation. As a key immune checkpoint, CTLA-4 is a major target in cancer immunotherapy. The 9D9 antibody is widely used for CTLA-4 blockade and has been shown in multiple tumor models to mediate effective in vivo depletion of intratumoral regulatory T cells. |
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| Form | Liquid |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b, kappa |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin Level | <1 EU/mg |
| Applications | in vivo CTLA-4 neutralization, WB, in vivo intra-tumoral regulatory T cell depletion |
| Species Reactivity | Mouse |
| Target | CD152, Cytotoxic T-lymphocyte protein 4, CTLA-4, CTLA4, Cytotoxic T-lymphocyte-associated antigen 4 |
| Storage Buffer | 0.01M PBS, pH 7.4. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Accession Number | P09793 |
| Note | For research use only. |
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