InVivo Plus Mouse PD-1 Antibody(RMP1-14)
- Cat. No.：RB9TMS870039
- Price：Negotiable
- Clicks：242
Product Detail
Product Parameters
| Product Description | The RMP1-14 monoclonal antibody recognizes mouse PD-1 (CD279), a 50–55 kDa CD28-family receptor transiently expressed on thymocytes, activated T and B cells, and myeloid cells. PD-1 contains an ITIM motif and delivers inhibitory signals upon engagement with its ligands PD-L1 and PD-L2, reducing T-cell activation and promoting peripheral tolerance. PD-1 deficiency in mice leads to autoimmunity, while PD-L1 upregulation in tumors enhances resistance to CD8 T-cell–mediated killing. Blocking the PD-1/PD-L1 pathway can inhibit tumor growth in mouse models. RMP1-14, like J43, effectively blocks PD-1 binding to both PD-L1 and PD-L2. |
|---|---|
| Form | Liquid |
| Host Species | Rat |
| Clonality | Monoclonal |
| Isotype | IgG2a, kappa |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin Level | <1 EU/mg |
| Applications | in vivo blocking of PD-1/PD-L signaling |
| Species Reactivity | Mouse |
| Target | Programmed cell death protein 1, Protein PD-1, mPD-1, CD279, Pdcd1, Pd1 |
| Storage Buffer | 0.01M PBS, pH 7.4. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Accession Number | Q02242 |
| Note | For research use only. |
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