InVivoMAb anti-Human APP Antibody
- Cat. No.：RB9THY235010
- Price：Negotiable
- Clicks：438
Product Detail
Product Parameters
| Product Description | mAb158 is a monoclonal antibody that selectively targets soluble Aβ protofibrils, a highly toxic aggregate species implicated in Alzheimer’s disease. It forms antibody–Aβ complexes that are more efficiently cleared and prevent the intracellular accumulation of Aβ in astrocytes, a cell type known to store rather than degrade protofibrils. By reducing protofibril load, mAb158 also protects neurons from Aβ-induced cell death, highlighting its ability to counteract secondary neurotoxicity mediated by astrocytes. |
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| Form | Liquid |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a, kappa |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Concentration | 1.38 mg/ml |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, Neutralization |
| Species Reactivity | Human |
| Target | Amyloid-beta precursor protein, APP, ABPP, APPI, Alzheimer disease amyloid A4 protein homolog, Alzheimer disease amyloid protein, Amyloid precursor protein, Amyloid-beta (A4) precursor protein, Amyloi |
| Storage Buffer | 0.01M PBS, pH 7.4. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Accession Number | P05067 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
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