InVivoMAb anti-Human PD-1 Antibody
- Cat. No.：RB9THS870010
- Price：Negotiable
- Clicks：481
Product Detail
Product Parameters
| Product Description | D12 is a fully human monoclonal antibody targeting PD-1, isolated from the synthetic AMG phage display library. It binds a novel epitope on PD-1 and induces an unusual conformational change at the receptor’s N-terminus. Despite limited overlap with the natural ligand-binding site, D12 effectively blocks PD-1 interaction with PD-L1 and PD-L2 through steric hindrance. The antibody shows high-affinity binding, recognizes PD-1 on activated human T cells, and cross-reacts with Cynomolgus monkey PD-1. |
|---|---|
| Form | Liquid |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Concentration | 1 mg/ml |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, Neutralization |
| Species Reactivity | Human |
| Target | Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279 |
| Storage Buffer | 0.01M PBS, pH 7.4. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Accession Number | Q15116 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
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