Recombinant Human IL-17A
- Cat. No.：EPT053
- Price：Negotiable
- Clicks：1081
Product Detail
Basic Information
| Size | 10ug |
|---|---|
| Expression Host | E.coli |
| Tag | NA |
Physical Properties
| Molecular Weight | 15.26 KDa |
|---|---|
| Apparent Molecular Weight | 16 KDa, reducing conditions |
| Form | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
Activity & Endotoxin
| Endotoxin Level | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
|---|---|
| Activity | Immobilized Human IL-17A(Cat#C021) at 2μg/ml (100 μl/well) can bind Anti-Human IL-17A mAb(Cat#NC012).The ED50 of Anti-Human IL-17A mAb(Cat#NC012) is 0.185 ug/ml. |
Storage & Shipping
| Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
|---|---|
| Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping Condition | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Detailed Description
| Background | Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
|---|
Related Products:
| Product Name | Clicks |
|---|---|
| 杀螟硫磷-BSA（或OVA）抗原 | 5027 |
| 二嗪磷-BSA（或OVA）抗原 | 5152 |
| 甲基对硫磷-BSA（或OVA）抗原 | 5190 |
| 氯苯那敏-BSA（或OVA）抗原 | 5010 |
| 水胺硫磷-BSA（或OVA抗原） | 4990 |
| 泰拉霉素-BSA（或OVA）抗原 | 5205 |
| 二甲戊灵-BSA（或OVA）抗原 | 5297 |
| 腐霉利-BSA（或OVA）抗原 | 5105 |
| 甲基睾酮-BSA（或OVA）抗原 | 5174 |
| 醋酸美伦孕酮-BSA（或OVA）抗原 | 5078 |
| 硝呋烯腙-BSA（或OVA）抗原 | 5175 |
| 倍他米松-BSA（或OVA）抗原 | 5325 |
| 福莫特罗-BSA（或OVA）抗原 | 4979 |
| 替硝唑-BSA（或OVA）抗原 | 4934 |
| 布洛芬-BSA（或OVA）抗原 | 5127 |
| 地昔尼尔-BSA（或OVA）抗原 | 5105 |
| 2,4,5-三氯苯氧乙酸-BSA（或OVA）抗原 | 4824 |
| 4-氯苯氧乙酸-BSA（或OVA）抗原 | 5091 |
| 赤霉素-BSA（或OVA）抗原 | 5253 |
| 6-苄氨基嘌呤-BSA（或OVA）抗原 | 5021 |