Recombinant Human IL-17A
- Cat. No.：EPT053
- Price：Negotiable
- Clicks：1114
Product Detail
Basic Information
| Size | 10ug |
|---|---|
| Expression Host | E.coli |
| Tag | NA |
Physical Properties
| Molecular Weight | 15.26 KDa |
|---|---|
| Apparent Molecular Weight | 16 KDa, reducing conditions |
| Form | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
Activity & Endotoxin
| Endotoxin Level | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
|---|---|
| Activity | Immobilized Human IL-17A(Cat#C021) at 2μg/ml (100 μl/well) can bind Anti-Human IL-17A mAb(Cat#NC012).The ED50 of Anti-Human IL-17A mAb(Cat#NC012) is 0.185 ug/ml. |
Storage & Shipping
| Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
|---|---|
| Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping Condition | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Detailed Description
| Background | Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
|---|
Related Products:
| Product Name | Clicks |
|---|---|
| 三唑酮（三唑醇）-BSA（或OVA）抗原 | 4904 |
| 甲霜灵-BSA（或OVA）抗原 | 5058 |
| 阿伐那非-BSA（或OVA）抗原 | 5075 |
| 异丙威-BSA（或OVA）抗原 | 4599 |
| 甲萘威-BSA（或OVA）抗原 | 5029 |
| 百草枯-BSA（或OVA）抗原 | 4864 |
| 西布特罗-BSA抗原 | 4996 |
| 马喷特罗-BSA抗原 | 4929 |
| 溴布特罗-BSA抗原 | 5009 |
| 马布特罗-BSA抗原 | 4919 |
| 左炔诺孕酮-BSA（或OVA）抗原 | 4910 |
| 二氢睾酮-BSA（或OVA）抗原 | 4921 |
| 辣椒碱（辣椒素）-BSA（或OVA）抗原 | 4395 |
| 联苯菊酯-BSA（或OVA）抗原 | 5208 |
| 美洛昔康-BSA（或OVA）抗原 | 5051 |
| 克百威-BSA（或OVA）抗原 | 5062 |
| 吡虫啉-BSA（或OVA）抗原 | 5107 |
| 多菌灵-BSA（或OVA）抗原 | 4994 |
| 安乃近代谢物（4-甲氨基安替比林）-BSA（或OVA）抗原 | 4986 |
| 氟虫腈-BSA（或OVA）抗原 | 5106 |