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Recombinant 2019-nCoV Guanine-N7_meth (N-6His)
- Cat. No.：EPT003
- Price：USD $ 5,400.00
- Clicks：943
Product Detail
Basic Information
| Size | 50ug |
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| Expression Host | E.coli |
| Tag | N-6His |
Physical Properties
| Molecular Weight | 62.9 KDa |
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| Apparent Molecular Weight | 60 KDa, reducing conditions |
| Form | Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4. |
| Purity | Greater than 85% as determined by reducing SDS-PAGE. |
Storage & Shipping
| Storage | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
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| Shipping Condition | The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
Detailed Description
| Background | The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14. |
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