Product Detail
基本信息
| Size | 50ug |
|---|---|
| Expression Host | Human Cells |
| Tag | C-mFc |
物理性质
| Molecular Weight | 110 KDa |
|---|---|
| Apparent Molecular Weight | 110-140 KDa, reducing conditions |
| Form | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl<sub>2</sub>, 10% Glycerol, pH 7.4. |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
活性与内毒素
| Endotoxin Level | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
|---|---|
| Activity | Immobilized 2019-nCoV S1 Protein (Cat#DRA35)at 10μg/ml (100μl/well) can bind Human ACE-2-mFc(Cat#C06A). The ED50 of Human ACE-2-mFc(Cat#C06A) is 45.11 ng/ml. |
储存与运输
| Storage | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
|---|---|
| Shipping Condition | The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
详细说明
| Background | Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function. |
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